Domain Insertions in Protein Structures
نویسندگان
چکیده
منابع مشابه
A Systematic Study of Homologous Protein Structures with Insertions/deletions
Sequence insertions/deletions (indels) represent one of the mechanisms of protein evolution. Alternative splicing (AS), considered as the major means of expanding structural and functional diversity in eukaryotes, can generate protein isoforms with indels when compared to the reference splicing variant. Knowledge of the effect of indels on the structural changes of the isoform structures is ess...
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Splicing requires reversible phosphorylation of serine/arginine-rich (SR) proteins, which direct splice site selection in eukaryotic mRNA. These phosphorylation events are dependent on SR protein (SRPK) and cdc2-like kinase (CLK) families. SRPK1 phosphorylation of splicing factors is restricted by a specific docking interaction whereas CLK activity is less constrained. To understand functional ...
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The CATH database of protein domain structures classifies structures according to their (C)lass, (A)rchitecture, (T)opology or fold and (H)omologous family (http://www.biochem.ucl.ac.uk/bsm/cath). Although the protocol used is mostly automatic, manual inspection is used to check assignments at some critical stages, such as the detection of very distantly related homologues and anologues and the...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2004
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2004.03.039